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Planes infested with the vampire strain are landing at major airports throughout the world. The fall of Mankind has begun. The Master Vampire, Jusef Sardu, barely survived Professor Abraham Setrakian's assault; his burnt body is rapidly decomposing; he needs a new host. Sardu sends his army of strigoi (recently transformed vampires) to destroy Setrakian and Eph Goodweather (of the CDC) and all their friends who are hiding out at the Knickerbocker Loans and Curios in Spanish Harlem. Meanwhile, Setrakian and Eph plan to bid for the Occido Lumen (a.k.a. the Silver Codex) at an auction at Sotheby's; this manuscript describes how to kill Sardu.

From back of book: In The Fall, the second book in the trilogy, the vampiric virus unleashed in The Strain has taken over New York City. It is spreading across the country and soon, the world. Amid the chaos, Eph Goodweather, head of the CDC's team, leads a small group in the fight against the bloodthirsty beasts that roam the streets. But it may be too late.

Ignited by the Master's horrific plan, a war erupts between Old and New World Vampires, each side vying for control of the planet. As the virus continues to plague the land, humans find themselves caught in the middle of the conflict...and at the bottom of the food chain. They are no longer the consumers, but the consumed.

At the same time, the battle finds its way inside Eph's own family: his ex-wife, Kelly, who was turned by the Master, has her sights fixed on Zack, Eph's son.

With the future of the world in the balance, Eph and his team, guided by the brilliant former professor and Holocaust survivor Abraham Setrakian and exterminator Vasiliy Fet, and joined by a crew of ragtag gangsters, must combat a terror whose ultimate plan is more terrible than humans imagined--a fate worse than annihilation.

(Source: William Morrow)